CHARLES CHIU

M.D., PH.D, ASSOCIATE. PROF., UCSF LAB. MED. & INFEC. DISEASES, DIRECTOR, UCSF-ABBOTT VIRAL DX & DISCOVERY CENTER

Dr. Chiu is an expert in the development and implementation of advanced genomic technologies for pathogen discovery and clinical diagnostics, including microarrays and next-generation sequencing, for a variety of blood-borne infections. His efforts in Lyme disease focus on the development of diagnostics for both pathogen detection and host response. He uses next-generation sequencing and has developed the “TickChip” to directly detect the RNA of Lyme bacteria and other tick-borne pathogens. He is also using RNA-sequencing technology to detect and identify a diagnostic profile of the body’s response to being infected by Lyme disease. He recently published in the highly prestigious New England Journal of Medicine, as described in a New York Times article, about the ability to uniquely and expeditiously diagnose a disease caused by an uncommon bacterial pathogen, Leptospira santarosai.

 

Changing the Point-of-Care Setting for Precision Medicine in Infectious Diseases

Emerging approaches in precision medicine such as metagenomic sequencing and transcriptome profiling are rapidly changing the point-of-care landscape in infectious diseases.  The increasing availability of disruptive technologies such as nanopore sequencing and state-of-the-art bioinformatics pipelines such as SURPI (sequence-based ultra-rapid pathogen identification) will facilitate rapid adoption in clinical and public health laboratories. For a CIAPM (California Initiative to Advance Precision Medicine)-funded multi-institution demonstration project, a single metagenomic sequencing test will be seamlessly combined with data from the  electronic medical record to provide real-time, clinically actionable information to guide diagnosis and treatment of hospitalized patients with life-threatening infectious diseases.

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