CHARLES CHIU

M.D., Ph.D, Asst. Prof., UCSF Lab. Med. & Infec. Diseases, Director, UCSF-Abbott Viral Dx & Discovery Center

Dr. Chiu is an expert in the development and implementation of advanced genomic technologies for pathogen discovery and clinical diagnostics, including microarrays and next-generation sequencing, for a variety of blood-borne infections. His efforts in Lyme disease focus on the development of diagnostics for both pathogen detection and host response. He uses next-generation sequencing and has developed the “TickChip” to directly detect the RNA of Lyme bacteria and other tick-borne pathogens. He is also using RNA-sequencing technology to detect and identify a diagnostic profile of the body’s response to being infected by Lyme disease. He recently published in the highly prestigious New England Journal of Medicine, as described in a New York Times article, about the ability to uniquely and expeditiously diagnose a disease caused by a bacteria that is in the same family as Lyme disease.

 

Genomic Approaches for Pathogen and Infectious Disease Diagnosis

Identification of genetic signatures for pathogens in clinical samples is a promising approach for the diagnosis, management, and treatment of patients with unknown infections.  The potential and pitfalls of emerging genomic technologies for infectious disease diagnostics — metagenomics, real-time nanopore sequencing, probe-based sequence enrichment, and human host transcriptome profiling — will be discussed.

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