Ph.D., Executive Vice President/Chief Scientific Officer, Geisinger Health
Dr. Ledbetter is executive vice president and chief scientific officer at Geisinger Health System. Previously he was the Robert W. Woodruff professor and director of the Division of Medical Genetics in the Department of Human Genetics at Emory University School of Medicine. He held academic and leadership positions at the University of Chicago, the National Center for Human Genome Research (now NHGRI) and Baylor College of Medicine. He is a graduate of Tulane University and earned his doctorate at the University of Texas-Austin. He has focused his research efforts on discovering the underlying etiology of childhood developmental disabilities.
Session: Large-Scale Genomics Projects
Data in isolation is of very limited value, and therefore one should be careful with drawing big conclusions from it. To be able to properly interpret complex data, large contextual data is the preferred starting point. This guidance certainly applies to genomics data. Large-scale genomics projects are defining and leading the way of transitioning genomics’ reach into the clinic. Numerous public and commercial efforts are under way that will be discussed in this session. In detail, we will hear about large-scale next-generation sequencing and omics projects, their goals, designs and specific applications, and the challenges encountered to extract knowledge for disease understanding, diagnosis, and treatment.
Geisinger’s Precision Health Initiative
Geisinger Health System, in partnership with the Regeneron Genetics Center, is conducting whole exome sequencing (WES) on 250,000 participants consented for access to longitudinal EHR/clinical data (average 12 years), broad recontact, and return of clinically actionable results. At present, >50,000 WES have been completed by Regeneron and return of results has been initiated.