IRV WEISSMAN

PIONEER IN REGENERATIVE MEDICINE AND CANCER STEM CELLS, RECOGNIZED AS THE "FATHER OF HEMATOPOIESIS"

M.D., Director, Inst. of Stem Cell Biology & Regenerative Medicine, Stanford School of Medicine

From 1988-1992, Dr. Weissman and his colleagues isolated the first blood-forming stem cells in mice and humans and successfully isolated human Leukemia cancer stem cells in 2000. His laboratories also discovered the human HSC, a human brain-forming stem cell population, mouse skeletal muscle stem cells, and an osteochondral stem cell in mice. His work and discoveries on stem cell aging contributed to the understanding of cancer stem cells and the immune system and are pioneering achievements with far-reaching clinical applications. Most recently, Dr. Weissman and his colleagues have identified a protein, CD47, that is highly expressed during the late stages of cancer stem cell progression and is currently being studied as a potential cancer therapeutic. Dr. Weissman, a proven leader in the field of cancer stem cell biology, also founded three companies focused on bringing stem cell therapies into the clinic. He was also on the founding Scientific Advisory boards of companies Amgen, DNAX, and T Cell Sciences.

 

Normal and Cancer Stem Cells: Biology and Translation

Purified blood forming stem cells [HSC] are the cornerstone of regenerative medicine. The transition from HSC to leukemia stem cells occurs in HSC clones. CD47, a don’t eat me signal arises at the final stage on all cancers, and blocking antibodies lead to removal of cancer cells by macrophages.

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