M. Sc., Staff Scientist, Fred Hutchinson Cancer Research Center

Jacob Kennedy is a staff scientist in the Paulovich laboratory at the Fred Hutchinson Cancer Research Center.  Since joining the group in 2009, he has led an international effort to develop and distribute analytically validated Multiple Reaction Monitoring (MRM) assays to large suites of human proteins (published in Nature Biotechnology) and has been part of a large scale project that developed MRM assays to demonstrate a discovery-to-validation biomarker pipeline (published in Nature Biotechnology). More recently, he has spearheaded the development of a one-step IMAC-MRM platform, as well as optimizing MRM and immuno-MRM assays on archived, FFPE tissues.

Precision Medicine: One Scientist’s Perspective

Cancer treatments don’t account for inter-patient variation. Assays are needed to facilitate personalized medicine. Genomic markers (“actionable mutations”) are used to make inferences about protein activities, yet they are poorly correlated to proteins and thus have not resulted in cures. MRM-based assays enable multiplex quantification of proteins from cancer biospecimens.

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