Ph.D., Senior Scientist, Immunology, Tissue Growth and Repair Diagnostics Discovery, Genentech
Michael Townsend received his Ph.D. in Immunology from the MRC Laboratory of Molecular Biology in Cambridge, UK followed by a postdoctoral fellowship at the Harvard School of Public Health in Boston, MA. He joined Genentech in 2005 and runs a laboratory focused on disease heterogeneity research and biomarker discovery in the Rheumatology area with particular interests in the pathophysiology and heterogeneity of Rheumatoid Arthritis and Systemic Lupus Erythematous. In 2015 he also became the department head for the Immunology, Tissue, Growth and Repair Department at Genentech with responsibility for biomarker discovery across autoimmune, pulmonary, infectious disease and neurological disease areas.
Disease Heterogeneity and Drug Response in Rheumatoid Arthritis
While effective therapies are approved for RA, not all patients demonstrate robust clinical responses. One reason for this relates to differences in disease pathophysiology. I will review some of the approaches that have been taken to define this underlying heterogeneity, and discuss how this can inform biomarker discovery.